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Panacea is home to a variety of local businesses, including seafood restaurants, an aquarium, bait and tackle shops, and RV parks. Whether you visit for lunch, a day on the water, or a weekend get-away, there’s something for everyone in Panacea.

Mineral Springs Seafood

1612 Coastal Hwy, Panacea, 32346

Mineral Springs Seafood is a market offering fresh and local seafood. They provide their own seafood along with several other local fishermen. They specialize in smoked fish, homemade smoked fish dips, deviled crab, stuffed bacon wrapped shrimp, crawfish, and alligator. Known for their great customer service and wide seafood selection.

My Way Seafood

1249 Coastal Hwy, Panacea, 32346

Fresh Florida seafood market, including Shrimp, Grouper, Mullet, Red Snapper, Oysters, and more. Family owned and operated for over 35 years, they are well known in the region for their excellent selection and customer service.

Outlaw Oysters

11 Rock Landing Road, Panacea, 32346

Outlaw Oyster Company is a wholesale and retail oyster distributor in the Southeast. Founded by two locals who love the water and formerly raised millions of oysters themselves, they now buy oysters from all the local farms, process them, and sell them wholesale and retail, and sell oyster farming equipment and supplies nationally. They also participate in local and regional festivals.


Posey’s Steam Room and Oyster Bar

1506 Coastal Hwy, Panacea, FL 32346

An institution in Panacea, Posey’s Steam Room and Oyster Bar is a local restaurant providing fresh seafood and southern cuisine. Locally owned, they provide the option to bring your own fish and they’ll cook it for you or choose they have locally steamed and seasoned shrimp or blue crabs. Of course, oysters are also available in a variety of ways: on the half-shell, steamed, fried, baked with bacon and cheese, or baked with garlic and Parmesan. The fried mullet and flounder are well regarded as a house specialty.

Saucy Lady Oysters

56 Jer-Be-Lou Blvd., Panacea, 32346

Saucey Lady Oyster Company was founded in 2014 by Tim Jordan and Walt Dickson.  Tim and Walt are charter members of an oyster growing program initiated by The TCC Wakulla Environmental Institute (WEI) to promote aquaculture and create jobs in the economically challenged coastal communities of Wakulla County. Saucey Lady Oyster Company utilizes the Australian Long Line method of producing oysters. Their oysters are grown off the bottom of the bay in baskets to protect them from predators and ensure them the nutritional benefits of the water column.

Seineyard at Rock Landing

99 Rock Landing Rd, Panacea, 32346

Family owned and operated; Seineyard at Rock Landing is a favorite local seafood restaurant in Panacea. They offer oysters on the 1/2 shell, Fresh Fried Mullet, and other Local Seafood right on the water. Visitors can arrive by land or gulf, as they offer a place to dock boats. The Seineyard always has live music on weekends and lunch specials plus full catering options for the area. 

Tropical Trader Shrimp Company

91 Coastal Hwy, Panacea, 32346

A local restaurant and oyster bar, Tropical Trader Shrimp Company serves fresh seafood in a casual dining atmosphere. In addition to fresh food, they are also a full-service seafood market, utilizing their own fleet of boats on the Gulf. Visitors can select any fish from the market for their meal or bring their own catch for the kitchen to prepare.





Big Bend Maritime Center

12 Crum Dr, Panacea, 32346

The Big Bend Maritime Center is a 501 C (3) organization run out of the Larry Tucker Watercraft Center with the support of The Wakulla County Board of Commissioners and local sponsors. The Center primarily operates through boatbuilding classes and camps for people of all ages. These classes include general woodworking and safety lessons, as well as the opportunity to build an entire boat from the bottom up. Volunteers also travel in the Big Bend area to a variety of festivals and boat shows doing live boatbuilding demonstrations.

Fishing Charters

Panacea, FL

Located on the shores of Dickerson and Levy Bay, with easy access to the Gulf and a variety of other fishing locations, Panacea is a hot spot for locally owned expert charter companies. These charters have the option of inshore flats fishing, Shark fishing, tarpon, bowfishing, gigging, and more. Visitors can expect options for trout fishing, red fishing, shark fishing, cobia fishing, triple tail, bass, bream, scalloping, bow fishing, and everything in between. Many charters also do eco tours, sunset cruises, or specialized trips. Some of the locally owned companies include: Panacea Outfitters, Tide Creek Charters, Boundless Fishing Adventures, Tripl3 Threat Fishing Charters, Viking Coastal Charters, and Reel Integrity Charters.

Gulf Specimen Marine Laboratory & Aquarium

1506 Coastal Hwy, Panacea, FL 32346

At Gulf Specimen Marine Laboratory in Panacea, you begin to get a better sense of what’s really out there. On a quiet back street between the highway and the bay, we house a collection of sea water tanks and aquariums. Water bubbles and flows in a swirl that sustains unique collections of the bizarre and the beautiful. Unlike most big public aquariums that emphasize porpoises and big fishes, we focus on creatures such as seahorses and hermit crabs, emerald eyed spiny box fish, electric rays and red and white spotted calico crabs – just a few of the the endless living treasures of north Florida’s still shining coast.

Children must be supervised. Certain tanks are “Looking Only” while others you are allowed to touch. When you purchase your ticket to the aquarium, you will be informed on which tanks are touching and not touching. The tanks will also have signs indicating whether they are “Looking” or “Touching.” Do not put your hands near the water or on the rim of the tank for the “Looking” tanks! Our animals associate people with food and may have sharp teeth. Make sure children are always accompanied by an adult when in the aquarium.

Holiday Park & Campground

14 Coastal Hwy, Panacea, 32346

Located right on the shores of Ochlockonee Bay, Holiday Park and Campground is conveniently located just outside of downtown Panacea, and within easy distance to some of the region’s most popular attractions. Visitors stay everywhere from one night to a couple weeks or a couple months. In addition to the beach, playground equipment, recreation room, fire pits, Wi-Fi, and other amenities, the Campground hosts multiple events a year. 

Panacea RV Park

1089 Coastal Hwy, Panacea, FL 32346

Located less than a mile from public boat ramps and Rock Landing Marina, Panacea RV Park is on the edge of the Apalachicola National Forest. Visitors can bring their own boat or provided information on renting one at Rock Landing. Cable, WI-FI, water and sewer are included, with daily and monthly rates available.  The Park is also pet friendly.

Wakulla County Airport

34 Monocoupe Cir, Panacea, 32346

Wakulla County Airport is a county-owned, public-use airport located three nautical miles south of downtown Panacea, adjacent to Tarpine, a fly-in/live-in community with through-the-fence operations. The airport has been in operation for 46 years. With the addition of 20 private T-hangars, the needs of this airport will be met well into 2020. The airport is located on 15 acres and additional acreage adjacent to the airport is being sought.  The Wakulla County Airport has one grass runway, which is 2,590 feet long by 70 feet wide and is in good condition.





Crum’s Mini Mall

1321 Coastal Hwy, Panacea, 32346

Crum’s Mini Mall is a one stop shop for fishing bait, fishing tackle, hardware, marine hardware, swimwear, beach supplies, gifts, souvenirs, gas & diesel and much more. Locally owned for over 40 years, their in-store stock includes over 400 fishing rods, live and frozen bait, marine supplies, marine and home hardware, and souvenirs.

Mike’s Marine Supply

1296 Coastal Highway Panacea, 32346

Mike’s Marine Supply specializes in providing a well-rounded inventory of boats, trailers, parts and accessories; great customer service; expert repair; boat motors outboard sales; and fishing boats for sale. Mike's Marine Supply has been family owned and operated since October 1, 1970. Mike’s Marine Supply is committed to ensuring everyone who passes through their doors has a great fishing experience on the Gulf!

Ochlockonee Bay Realty

146 Coastal Hwy #2708, Panacea, 32346

Based out of Crawfordville and Panacea, Ochlockonee Bay Realty is the oldest real estate company in the Ochlockonee Bay Area. With their location in the Big Bend area, they serve a region including Wakulla property, Crawfordville homes, Woodville real estate, Panacea real estate, Sopchoppy property, St. Marks Florida homes, Spring Creek homes, Shell Point real estate, Ochlockonee Bay homes, Alligator Point vacation rentals, and Carabelle property. They also serve beyond the Ochlockonee area to St. Teresa, Bald Point, East Point, Lanark Village, St. George Island, Quincy, Havana, Wacissa, Lloyd, Tallahassee, and Monticello.

Rock Landing Marina

99 Rock Landing Road, Panacea, FL 32346

Rock Landing Marina is a full-service marina located on Dickerson Bay. They offer dry and wet slips, storage options, an onsite store, and concierge service for no additional charge. Customers can call ahead to have their boat in the water, full of fuel, oil, bait, ice, and any other necessary items. 

Sea Tow Big Bend

8 Jer-Be-Lou Blvd, Panacea, Florida

Sea Tow Big Bend has a dedicated team of captains, crew and support staff that are standing by, 24/7, to serve their members and other boaters. Their vessels are available for towing, ungrounding, jump starts, fuel delivery, and other on-water assistance operations. 

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